Multiflavor Streptavidin

The Portal is a joint project of MATTO and the MTTC. The development and implementation of the portal has been paid for by the MTTC, Beth Israel Deaconess Medical Center, Boston Biomedical Research Institute, Boston University, Brandeis University, Caritas St. Elizabeth's Medical Center, Boston Children's Hospital, Dana Farber Cancer Institute, Harvard University, Joslin Diabetes Center, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, McLean Hospital, Northeastern University, The Schepens Eye Research Institute, and Tufts University.

Intellectual Property

ID:		97-22
IP Type:		Licensable Technology
Title:		Multiflavor Streptavidin
Inventor:		Cantor, Charles R.
Summary:		Compounds and methods are described for producing streptavidin mutants with greater affinity for biotin substitutes than for biotin. The compounds and methods of the present invention are particularly useful where levels of endogenous biotin are present in the system, precluding the use of the standard biotin-avidin approach. In addition, it is contemplated that the streptavidin-biotin system can be used as a model to test if the contacts that exist between a protein and a ligand can serve as the starting point to genetically engineer the protein to develop a high specificity for another ligand. The strategy is contemplated to be useful to develop a receptor for a molecule without a known receptor when phage-display methodologies cannot be employed, such as in the case of a multi-chain protein, for the discovery of new drugs and diagnostic reagents, or in applications where the use of one molecule is well-suited for a project but the other one is not.
Tech Type:		Research Tools \| Research Reagents
URL:		http://ctf-fmfe.bu.edu/BU9722.pdf
Contact:		Harald Steltzer, cives@bu.edu, 617 358 4550
Organization:		Boston University

Display all intellectual properties for Cantor, Charles R.
Display all intellectual properties for Boston University