Reduced Affinity Streptavidin (also) Streptavidin Mutants

The Portal is a joint project of MATTO and the MTTC. The development and implementation of the portal has been paid for by the MTTC, Beth Israel Deaconess Medical Center, Boston Biomedical Research Institute, Boston University, Brandeis University, Caritas St. Elizabeth's Medical Center, Boston Children's Hospital, Dana Farber Cancer Institute, Harvard University, Joslin Diabetes Center, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, McLean Hospital, Northeastern University, The Schepens Eye Research Institute, and Tufts University.

Intellectual Property

ID:		94-53
IP Type:		Licensable Technology
Title:		Reduced Affinity Streptavidin (also) Streptavidin Mutants
Inventor:		Cantor, Charles R.
Summary:		The invention relates to a mutated streptavidin protein having a reduced affinity for biotin and to methods which involve this recombinant protein. Reduced affinity allows for the use of the streptavidin-biotin coupling systems for detectoin and isolation systems wherein it is necessary to remove one or the other of the binding partners. Such systems are useful for the purification of functional proteins and viable cells. The invention also relates to nucleic acids which enode reduced affinity streptavidin protein and to recombinant cells which contain these nucleic acids. The invention overcomes the problems and disadvantages associated with current strategies and designs and provides a streptavidin protein with reduced affinity for biotin and methods fro utilizing reduced affinity streptavidin in detection and isolation.
Tech Type:		Research Reagents \| Research Tools
URL:		http://ctf-fmfe.bu.edu/BU9453.pdf
Contact:		Rick T. Clark, cives@bu.edu, 617 358 4550
Organization:		Boston University

Display all intellectual properties for Cantor, Charles R.
Display all intellectual properties for Boston University