Use of Electrostatic Fields to Enhance Surface Plasmon Resonance Spectroscopy

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Intellectual Property

ID:		00-65
IP Type:		Licensable Technology
Title:		Use of Electrostatic Fields to Enhance Surface Plasmon Resonance Spectroscopy
Inventor:		Georgiadis, Rosina M.
Summary:		This invention presents a novel, yet extremely simple, method for mutation detection based on purely electrostatic charging effects. The method allows effective discrimination between matched and mismatched hybrids. This sequence selectivity in hybrid denaturation imparts an extremely high stringency for assaying DNA interactions. The invention avoids the limitations of most current technologies for the detection of nucleic acid interactions with immoblizied oligonucleotide probes for DNA microarray applications, improving the stringency and speed of biomolecular interactions at interfaces.
Tech Type:		Sensing/Imaging \| Microarrays
URL:		http://ctf-fmfe.bu.edu/BU0065.pdf
Contact:		Sean Lee, seanlee@bu.edu, 617 353 4567
Organization:		Boston University

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